Abstract

Fecal microbiome variation in the average, healthy population has remained under-investigated. Here, we analyzed two independent, extensively phenotyped cohorts: the Belgian Flemish Gut Flora Project (FGFP; discovery cohort; N = 1106) and the Dutch LifeLines-DEEP study (LLDeep; replication; N = 1135). Integration with global data sets (Ncombined = 3948) revealed a 14-genera core microbiota, but the 664 identified genera still underexplore total gut diversity. Sixty-nine clinical and questionnaire-based covariates were found associated to microbiota compositional variation with a 92% replication rate. Stool consistency showed the largest effect size, whereas medication explained largest total variance and interacted with other covariate-microbiota associations. Early-life events such as birth mode were not reflected in adult microbiota composition. Finally, we found that proposed disease marker genera associated to host covariates, urging inclusion of the latter in study design.

 

Science  29 Apr 2016:
Vol. 352, Issue 6285, pp. 560-564
DOI: 10.1126/science.aad3503

Authors: Gwen Falony, Marie Joossen, Sara Vieira-Silva, Jeroen Raes et al.

http://science.sciencemag.org/content/352/6285/560.abstract 

Our site uses cookies. We'll assume that you are OK with this if you browse further. To find out more about the cookies we use, see our Cookie Policy.

I accept cookies from this site