Scientific Publications

A multiplexed targeted assay for high-throughput quantitative analysis of serum methylamines by ultra performance liquid chromatography coupled to high resolution mass spectrometry

Details
Published: 18 April 2016

Highlights

    • A mass spectrometry method for simultaneous assay of methylamines is proposed.
    • The analytical method is validated for implementation in clinical settings.
    • Correlations between abundance of metabolites in human serum is established.
    • Gender differences in abundance of serum metabolites are reported.

 

Authors: Hanane Kadar, Justine Dubus, Jérémie Dutot, Lyamine Hedjazi, Suman Srinivasa, Kathleen V. Fitch, Steven K. Grinspoon, Jeremy K. Nicholson, Marc-Emmanuel Dumas, Dominique Gauguier

Archives of Biochemistry and Biophysics

Volume 597, 1 May 2016, Pages 12–20

doi:10.1016/j.abb.2016.03.029

full article available here: 

http://www.sciencedirect.com/science/article/pii/S0003986116300820 

Key facts

Full Title: Metagenomics in Cardiometabolic Diseases

Scientific Coordinator: Karine Clément, INSERM

Budget: EU contribution €11,999,992 ; Total costs: €20,387,421 (balance provided by partners)

Partners: 14 partners in six countries

Timing: Project length is 60 months and commenced 01/11/2012

Clinicaltrials.gov registration here

Horizonhealth.eu here

EC Cordis record and reports here

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