Read more: biography and main publications
Biography
My first brushes with bioinformatics were by developing phylogenetics tools as a summer project back at Uppsala University. For my PhD at Stockholm University I wanted to move closer to clinical applications by work on how protein structure and function evolves and how it can be predicted, aiding in development of resources such as Pfam and InParanoid. For my post-doctoral project at EMBL Heidelberg, funded by the Alexander von Humboldt foundation, I wanted still closer to clinical relevance by analyzing evolution, composition, interaction and functional capacities of human-associated microbes. MetaCardis then realizes this intention, allowing me to apply a variety of computational tools, including sequence analysis, machine learning and evolutionary analysis, to attempting to solve an actual problem of human health. From May 1st 2018 I head a research group for host-microbiome high-throughput analysis in cardiovascular disease at the ECRC (joint centre between the Charité hospital and the Max Delbrück Centre) in Berlin.
Main Publications
- Wilck N, Matus MG, Kearney SM, Olesen SW, Forslund K, Bartolomaeus H, Jörg J, Mähler A, Balogh A, Markó L, Vvedenskaya O, Kleiner FH, Tsvetkov D, Klug L, Costea PI, Sunagawa S, Maier L, Rakova N, Schatz V, Neubert P, Frätzer C, Krannich A, Gollasch M, Grohme DA, Côrte-Real BF, Gerlach RG, Basic M, Typas A, Wu C, Titze JM, Jantsch J, Boschmann M, Dechend R, Kleinewietfeld M, Kempa S, Bork P, Linker RA, Alm EJ, Müller DM. (2015) Salt-responsive gut commensal modulates T H 17 axis and disease. Nature. 551(7682):585-589
- Pedersen HK, Gudmundsdottir V, Nielsen HB, Hyotylainen T, Nielsen T, Jensen BAH, Forslund K, Hildebrand F, Prifti E, Falony G, Le Chatelier E, Levenez F, Doré J, Mattila I, Plichta DR, Pöhö P, Hellgren LI, Arumugam M, Sunagawa S, Vieira-Silva S, Jørgensen T, Bak Holm J, Trošt K, MetaHit consortium, Kristiansen K, Brix S, Raes J, Wang J, Hansen T, Bork P, Brunak S, Oresic M, Ehrlich SD, Pedersen O. (2016) Human gut microbes impact host serum metabolome and insulin sensitivity. Nature 535, 376–381. doi:10.1038/nature18646. [PMID: 27409811]
- Korpela K, Salonen A, Virta LJ, Kekkonen RA, Forslund K, Bork P, de Vos WM. (2016) Intestinal microbiome is related to lifetime antibiotic use in Finnish pre-school children. Nat Commun. 2016 Jan 26;7:10410. doi: 10.1038/ncomms10410. [PMID: 26811868]
- Forslund K, Hildebrand F, Nielsen T, Falony G, Le Chatelier E, Sunagawa S, Prifti E, Vieira-Silva S, Gudmundsdottir V, Krogh Pedersen H, Arumugam M, Kristiansen K, Yvonne Voigt A, Vestergaard H, Hercog R, Igor Costea P, Roat Kultima J, Li J, Jorgensen T, Levenez F, Dore J; MetaHIT consortium, Bjorn Nielsen H, Brunak S, Raes J, Hansen T, Wang J, Dusko Ehrlich S, Bork P, Pedersen O. (2015) Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota. Nature. 2015 Dec 2. doi: 10.1038/nature15766. [PMID: 26633628]
Institute Number: 5